Endocrine Abstracts

Introduction: Denosumab reduces bone resorption, increases BMD, and reduces fracture risk. Denosumab discontinuation (DD) induces an increase of B-crosslaps above baseline values for two years, and a decrease of BMD values. This rebound effect is associated with spontaneous clinical vertebral fractures (SCVF) in close to 15% of patients considering a follow-up of 2 years without taking another osteoporosis treatment. Prescribing a bisphosphonate or SERMs at DD would prevent th...

Inguinal subcutaneous fat, the site of murine mammary glands 4 and 5, is a suitable model of mammary white fat adipose tissue (WAT). WAT requires extracellular Ca2+ influx for differentiation and expansion; this primarily occurs via plasma membrane Ca2+ voltage-dependent channels (CaVs). Whereas the neuropeptide oxytocin can mobilise intracellular Ca2+ in WAT which has key roles in lactation. Our aim was to use a combination of molecular biolog...

Introduction: Malnutrition and sarcopenia are interrelated and frequent in hospital settings, being related to a higher morbimortality. CIPA nutritional screening (performed at the Hospital Universitario Nuestra Señora de Candelaria) is positive when one or more of the following criteria is met: a) decreased oral intake in 72 h (<50%), b) albumin <3 g/dl, and c) BMI <18.5 g/m2 or mid-upper arm circumference (MUAC) ≤ 22.5 cm.<p class="abste...

Introduction: Adrenal myelolipomas are benign and fatty tumors usually detected incidentally in imaging tests. Their prevalence increases in patients with CAH, probably because corticosteroid deficiency causes high ACTH levels that stimulate adrenal growth, although their effect on the growth of adrenal tumors is not yet well established.Clinical case: A 41-year-old man with classic 21 OH deficiency, losing salt since he was 10 months old,with stable dos...

Introduction: Pregnancy involves distinct metabolic stages, initially characterized by maternal anabolism, followed by a catabolic phase driven by placental lactogen and various cytokines, leading to varying degrees of insulin resistance. DM is the most common metabolic disorder linked to pregnancy.Objective: The study aimed to detail the clinical characteristics, obstetric complications, and neonatal outcomes of patients with GDM and their children....

Introduction: T2DM is associated with an increased risk of fractures. This heightened risk is attributed to factors such as prolonged disease duration and chronic glycemic control. Interestingly, despite this increased fracture risk, patients with T2DM often exhibit normal or even elevated BMD compared to non-diabetic individuals. This phenomenon is thought to be a result of reduced bone remodeling, coupled with changes in bone microarchitecture.Objectiv...

Background: Cyclical Cushing syndrome (CCS) is a rare variant of Cushing syndrome (CS) characterized by periodic cycles of cortisol excess. Diagnosis of CCS is difficult because cortisol excess occurs unpredictably and often limited to short periods. We present 2 unusual cases where the patients developed severe prolonged life-threatening “square wave” hypercortisolemic phase followed by eucortisolemia, both phases extending > 3 months. Case 1: A 75 year old male...

Lipodystrophic syndromes are a heterogeneous group of usually rare disorders, which have in common the selective and irreversible deficiency of adipose tissue in the absence of nutritional deprivation or catabolic state. Clinically, they are characterized by insulin resistance, related to a state of hypoleptinemia, with manifestations such as polycystic ovarian syndrome, type 2 diabetes mellitus, severe hypertriglyceridemia, and steatohepatitis among their most frequent metabo...

The main product of the thyroid gland, T4, is a prohormone. 5’-deiodination is needed to convert T4 into the active, nuclear receptor-binding hormone, T3. Pharmacological modulation of activating 5’-and inactivating 5-deiodination of iodothyronines would be desirable in a number of medical conditions, including hypothyroidism, hyperthyroidism and various cancers. A structural and mechanistic understanding of deiodinase (DIO) catalysis...

Introduction: The aim of this report is to present the uncommon clinical presentation of a patient with a pancreatic NET.Case report: A 55-year-old man with personal history of hypertension, dyslipidaemia, and depression. He was referred to the outpatient for high levels of calcium in repeated assessments during the last year. He referred polyuria and polydipsia. Not clinical history of bone fractures, abdominal pain, or another digestive symptoms. Initi...